NLRP3 inflammasome and eye diseases
10.3760/cma.j.cn115989-20200325-00203
- VernacularTitle:NLRP3炎症小体与眼部疾病
- Author:
Yujian ZHANG
1
;
Min JI
;
Huaijin GUAN
Author Information
1. 南通大学附属医院眼科研究所 226001
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(4):365-368
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotide binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a set of intracellular protein complexes.NLRP3 inflammasome can trigger the activation of caspase-1 and contribute to the maturation of interleukin, and finally result in a series of inflammation responses in host.Inflammasomes are activated in a variety of cases, including multiple inflammation-related eye diseases, such as xerophthalmia, glaucoma, age-related macular degeneration and so on.This article aimed to interpret the effect and mechanism of the activation of NLRP3 inflammasome, and reviewed how the mutation of gene or the structure disturbance of protein related to NLRP3 inflammasome affects the occurrence and development of inflammation-related eye diseases.
