Pathophysiological changes in uninfected eye of unilateral infectious keratitis
10.3760/cma.j.issn.2095-0160.2020.03.011
- VernacularTitle:单眼感染性角膜炎患者健眼的病理生理变化
- Author:
Xintian LIU
1
;
Yan SHI
;
Hong ZHANG
Author Information
1. 哈尔滨医科大学附属第一医院眼科医院 150001
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(3):220-223
- CountryChina
- Language:Chinese
-
Abstract:
Infectious keratitis often occurs in single eye and causes changes in the nervous system, immune system and tear function, which may affect contralateral uninfected eye.Changes in the uninfected eye include a decrease in corneal nerve density and tear secretion, an increase in corneal dendritic cells and changes in tear cytokines.All the changes can be observed by in vivo confocal microscopy, Schirmer test I and tear film break-up time tests.Alternations in immune cells, cytokines and immunodulatory neuropeptide levels in contralateral eyes might mediate the incidence of bilateral infectious keratitis, and are also correlated with lacrimal reflex pathway.This article reviewed the pathophysiological changes in the contralateral uninfected eye of monocular infectious keratitis, which may help increase our understanding of the mechanisms involved in the corneal homeostasis and pathophysiology of corneal diseases.
