In vitroantimicrobial activity of diacerein on common ocular surface pathogens
10.3760/cma.j.issn.2095-0160.2020.03.002
- VernacularTitle:双醋瑞因对眼表常见病原菌的体外抑制作用
- Author:
Juan YUE
1
;
Shoujun JIAN
;
Qixue LYU
;
Shengtao SUN
;
Lei HAN
;
Susu LIU
;
Hongmin ZHANG
Author Information
1. 河南省人民医院眼科 河南省立眼科医院 河南省眼科研究所 河南省眼科学与视觉科学重点实验室 郑州大学人民医院眼科，郑州 450003
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(3):165-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the antimicrobial activity of diacerein on common pathogens of the ocular surface in vitro.Methods:Pathogens were collected from patients with ocular surface infections in Henan Eye Hospital, including Gram-positive cocci and bacilli, Gram-negative bacilli, filamentous fungi, and Candida.The antimicrobial activity of diacerein was determined by the K-B agar diffusion method, and its minimum inhibitory concentration (MIC) was determined by the micro-liquid method.Levofloxacin and voriconazole were used as the control of antibacterial and antifungal drug, respectirely.Results:Diacerein showed antibacterial activity against 42 strains of Gram-positive cocci and 10 strains of Gram-positive bacilli, its inhibition zone diameters for Staphylococcus epidermidis, S.aureus, S.intermedius and Gram-positive Corynebacterium were not significantly different from those of levofloxacin (all at P>0.05). Its MIC range of diacetate against Staphylococcus epidermidis, S. aureus, S. intermedius and other Staphylococci was 1-32 μg/ml, and its respective MIC 90 was 16, 8, 16, and 32 μg/ml.Diacerein had no bacteriostatic effect on 23 strains of Gram-negative bacilli, 10 strains of filamentous fungi and 3 strains of candida. Conclusions:Diacerein has antibacterial effects against Gram-positive Staphylococcus and Corynebacterium isolated from the ocular surface, but shows no antimicrobial activity against Gram-negative bacilli and fungi.Diacerein offers a new drug option and method for the treatment of bacterial keratitis.
