Randomized control study on the outcome of less invasive surfactant administration in premature infants
10.3760/cma.j.issn.2096-2932.2020.02.009
- VernacularTitle:早产儿肺表面活性物质微创给药随机对照研究
- Author:
Shan LI
1
;
Ying WANG
;
Tian SANG
;
Xifang RU
;
Qi FENG
Author Information
1. 北京大学第一医院儿科 100034
- Keywords:
Respiratory distress syndrome,newborn;
Pulmonary surfactants;
LISA;
INSURE
- From:Chinese Journal of Neonatology
2020;35(2):113-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the short-term outcomes of less invasive surfactant administration (LISA) with traditional intubate-surfactant-extubate (INSURE) method for respiratory distress syndrome (RDS) in premature infants.Method From January 2017 to December 2018,premature infants (gestational age ≤32 weeks) diagnosed with RDS who needed pulmonary surfactant (PS) administration were prospectively enrolled and randomly assigned into LISA group and INSURE group.The duration of oxygen supply,side effects during PS administration,the outcome and severe adverse events,bronchopulmonary dysplasia (BPD),necrotizing enterocolitis (NEC),3 ～ 4° periventricular intraventricular hemorrhage (PIVH),periventricular leukomalacia (PVL) and death were compared.Result A total of 67 cases were enrolled including 34 in LISA group and 33 in INSURE group.No significant differences existed between the two group on mechanical ventilation rates,oxygen therapy duration and the incidences of severe adverse events.However,the duration of noninvasive ventilation in LISA group was significantly longer than INSURE group [(10.5 ± 8.7) d vs.(7.1 ± 2.6) d,P ＜ 0.05].The LISA group had significantly higher PS reflux rate than INSURE group [41.2％ (14/34)vs.18.2％ (6/33),P ＜0.05].Conclusion LISA has similar clinical effects and severe adverse events as INSURE,but with higher rates of PS reflux and longer duration of noninvasive ventilation.
