The therapeutic effects of stored blood with low glucose 6-phosphate dehydrogenase activity for exchange transfusion in neonatal hyperbilirubinemia
10.3760/cma.j.issn.2096-2932.2020.02.007
- VernacularTitle:库存血葡萄糖-6-磷酸脱氢酶活性与新生儿高胆红素血症换血疗效的研究
- Author:
Guixiang ZENG
1
;
Shuying ZHANG
;
Yanping HUANG
;
Haihua CHEN
Author Information
1. 南宁市妇幼保健院新生儿科 530011
- Keywords:
Hyperbilirubinemia,neonatal;
Glucose 6-phosphate dehydrogenas deficiency;
Stored blood;
Exchange transfusion
- From:Chinese Journal of Neonatology
2020;35(2):104-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of stored blood with low glucose 6-phosphate dehydrogenase (G6PD) activity for exchange transfusion (ET) in neonate hyperbilirubinemia.Method From January 2017 to December 2018,all neonates receiving ET for neonatal hyperbilirubinemia in neonatology department of our hospital were prospectively enrolled.G6PD activity in stored blood and in these neonates were examined.Their demographic information and other clinical data including post-ET total serum bilirubin (TSB) decrease,post-ET phototherapy duration and total hospital stay duration were collected.Result A total of 99 cases were enrolled,51 cases with normal G6PD and 48 G6PD deficiency.Among normal G6PDneonates,those receiving low G6PD activity blood had less decrease of post-ET TSB [(56.9 ± 8.4) ％ vs.(72.5 ± 14.4) ％],longer hospital stay and longer post-ET phototherapy duration [(6.4 ± 2.3) d vs.(4.9 ± 1.3) d,(70.8 ± 36.2) h vs.(52.3 ± 16.3) h] (P ＜ 0.05) than those receiving normal G6PD blood.Among G6PD deficiency neonates,those receiving low G6PD activity blood had less decrease of post-ET TSB [(58.8 ±6.2)％ vs.(67.3 ± 13.9)％],longer hospital stay and longer post-ET phototherapy duration [(5.5 ± 2.2) d vs.(4.4 ± 1.4) d,(60.6 ± 25.9) h vs.(47.9 ± 27.9) h] (P ＜ 0.05) than those receiving normal G6PD blood.The G6PD activity in stored blood had significant influences on duration of phototherapy (F =7.695,P =0.007),duration of hospital stay (F =12.528,P =0.001) and decrease of post-ET TSB (F =29.025,P ＜ 0.001).Conclusion ET with low G6PD activity stored blood has less favourable effects with less post-ET TSB decrease and prolonged duration of phototherapy and hospital stay.
