The relationship between bronchopulmonary dysplasia and SP-B intron 4 gene polymorphism in Mongolian and Han newborns in Inner Mongolia
10.3760/cma.j.issn.2096-2932.2020.02.004
- VernacularTitle:内蒙古地区蒙汉族早产儿支气管肺发育不良与SP-B内含子4基因多态性的相关性研究
- Author:
Mengyue HUO
1
;
Hua MEI
;
Chunzhi LIU
;
Yuheng ZHANG
;
Chun XIN
;
Xin JIA
;
Fei YAN
;
Yanbo ZHANG
;
Yanan HU
Author Information
1. 内蒙古医科大学附属医院新生儿科
- Keywords:
Bronchopulmonary dysplasia;
Pulmonary surfactant-associated protein B;
Intron 4;
Genotype
- From:Chinese Journal of Neonatology
2020;35(2):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between pulmonary surfactant protein B (SP-B) intron 4 gene polymorphism and bronchopulmonary dysplasia (BPD) in premature infants.Method From January 2016 to January 2019,premature infants diagnosed with BPD in our hospital were selected as the BPD group,and non-BPD premature infants of the same ethnic group were selected as the control group.The genotype and allele distribution of SP-B intron 4 were analyzed using polymerase chain reaction (PCR)method.Result A total of 74 infants with BPD were included,including 30 Mongolian infants and 44 Han infants.A total of 134 cases were in the control group,including 56 Mongolian infants and 78 Han infants.Wild type and variant type (including insertion and deletion) could be detected in SP-B intron 4 gene in both Mongolian and Han infants.The frequencies of wild and variant genotypes and alleles in Mongolian BPD infants were similar with the control group [36.7％ (11/30) vs.19.6％ (11/56),21.7％ (13/60) vs.12.5％ (14/112)] (P ＞ 0.05).The frequencies of wild and variant genotypes and alleles in Han infants with BPD were significantly different from the control group [31.8 ％ (14/44) vs.12.8 ％ (10/78),20.5 ％(18/88)vs.7.1％(11/156)] (P＜0.05).Conclusion The variation of intron 4 gene in SP-B may be related with the genetic susceptibility of Han infants with BPD in Inner Mongolia.
