The clinical value of cerebrospinal fluid tumor necrosis factor-α and resolvin D1 in neonatal purulent meningitis
10.3760/cma.j.issn.2096-2932.2020.01.005
- VernacularTitle:肿瘤坏死因子α和消退素D1检测在新生儿化脓性脑膜炎中的意义
- Author:
Feng CHEN
1
,
2
;
Xiaoxiao HE
;
Na JIANG
;
Zhenlang LIN
;
Shangqin CHEN
;
Minli ZHU
Author Information
1. 温州医科大学附属第二医院(育英儿童医院)新生儿科 325027
2. 温州市人民医院儿童保健科 325000
- Keywords:
Meningitis,bacterial;
Tumor necrosis factor-alpha;
Resolvin D1;
Cerebrospinal fluid;
Infant,newborn
- From:Chinese Journal of Neonatology
2020;35(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of tumor necrosis factor-α (TNF-α) and resolvin D1 (RvD1) concentrations in cerebrospinal fluid (CSF) of neonatal purulent meningitis(NPM).Method From June 2016 to June 2017,neonates of suspected NPM admitted to the neonatology department of our hospital were studied prospectively.Their CSF was examined before the use of antibiotics.The patients were assigned into NPM group and non-NPM group.After 7 to 10 days of treatment,according to the clinical symptoms and the reexamination results of CSF,patients in the NPM group were further assigned into the improved group and the unimproved group.The levels of TNF-α and RvD1 in CSF were measured using enzyme-linked immunosorbent assay (ELISA) method,and SPSS 22.0 was used for statistical analysis.Result A total of 23 patients were included in the NPM group (18 in the improved group and 5 in the unimproved group) and 30 in the non-NPM group.The levels of TNF-α and RvD1 in the CSF of the NPM group were higher than the non-NPM group [TNF-α:(0.263 ±0.088) pg/ml vs.(0.087 ±0.001) pg/ml,RvD1:(2.017 ± 0.171) pg/ml vs.(0.563 ±0.048) pg/ml] (P ＜0.05).After 7 to 10 days of treatment,TNF-α and RvD1 decreased in the improved NPM group[TNF-α:0.083 (0.078,0.111) pg/ml vs.0.122 (0.098,0.214) pg/ml,RvD1:1.242 (0.740,2.098) pg/ml vs.1.791 (1.371,2.804) pg/ml] (P ＜ 0.05),and increased in the unimproved NPM group [TNF-α:2.239 (1.309,2.806) pg/ml vs.0.102 (0.100,1.312) pg/ml,RvD1:2.614 (1.265,2.940) pg/ml vs.0.139 (0.103,0.276) pg/ml] (P ＜ 0.05).The reexamination results of TNF-oα in the NPM group were lower than the examination results before the use of antibiotics of the non-NPM group,and RvD1 higher than the non-NPM group (P ＜ 0.05).Conclusion TNF-α and RvD1 in CSF have clinical value for the early diagnosis and therapeutic evaluation of NPM.
