Future in regenerative surgical discipline: construction engineered liver with optimized strategy of decellularized and recellularized technology
10.3760/cma.j.cn115610-20200519-00367
- VernacularTitle:未来再生外科学：优化脱细胞和再细胞策略构建工程化肝脏
- Author:
Leida ZHANG
1
;
Renpei XIA
;
Yujun ZHANG
;
Quanyu CHEN
;
Hongyu ZHANG
;
Lianhua BAI
Author Information
1. 陆军军医大学第一附属医院全军肝胆外科研究所，重庆 400038
- From:
Chinese Journal of Digestive Surgery
2020;19(7):795-798
- CountryChina
- Language:Chinese
-
Abstract:
End-stage liver disease (ESLD) is a serious threat to human health, and liver transplantation is the only effective treatment. However, most of the patients died in the process of waiting for transplantation due to the shortage of liver source. With the rapid development of biological tissue enginee-ring technology, researchers have established the strategy of 'decellularized and recellularized technology’, which has deve-loped into the first choice for construction of important organs such as the liver and opened up new ideas for the treatment of ESLD. At present, scientists are working on the optimization of this technology, in order to construction a functional 'new liver’ for transplantation. The authors review the feasibility and challenges of the application of this technology and its optimization stra-tegy in the field of regenerative surgery.
