Three Cases of Autoimmune Progesterone Dermatitis.
- Author:
Hye Rin YOU
1
;
Sook Jung YUN
;
Sung Jin KIM
;
Seung Chul LEE
;
Young Ho WON
;
Jee Bum LEE
Author Information
- Publication Type:Case Report
- Keywords: Autoimmune progesterone dermatitis; Menstrual cycle; Progesterone
- MeSH: Angioedema; Dermatitis*; Dermatitis, Contact; Drug Eruptions; Eczema; Erythema; Erythema Multiforme; Female; Humans; Intradermal Tests; Luteal Phase; Menstrual Cycle; Menstruation; Progesterone*; Rosacea; Skin; Skin Diseases; Steroids; Urticaria
- From:Annals of Dermatology 2017;29(4):479-482
- CountryRepublic of Korea
- Language:English
- Abstract: Autoimmune progesterone dermatitis is a rare cyclic premenstrual reaction to progesterone produced during the luteal phase of the menstrual cycle. The clinical symptoms of autoimmune progesterone dermatitis overlap with other forms of dermatosis such as erythema multiforme, eczema, fixed drug eruption, urticaria, and angioedema. We experienced 3 cases of autoimmune progesterone dermatitis. All patients had a recurrent history of monthly skin eruptions. Skin lesions normally began a few days before menstruation and resolved a few days later. Patients were confirmed to have autoimmune progesterone dermatitis by the results of the progesterone intradermal test. All three patients had different clinical findings such as erythema annulare centrifugum, urticaria, contact dermatitis, and rosacea. Because patients presented with variable clinical manifestations, they could have been easily misdiagnosed. The patients were treated with oral contraceptive, antihistamine and steroids for symptom control. We propose that dermatologists should consider autoimmune progesterone dermatitis in cases of recurrent cyclic skin eruptions in female patients. Further, if this condition is suspected, thorough history taking including that on menstrual cycle and intradermal progesterone test should be performed.
