Research advances in bile acid metabolism after cholecystectomy and its mechanism of inducing colorectal cancer
10.3760/cma.j.cn115610-20200419-00264
- VernacularTitle:胆囊切除术后胆汁酸代谢及其诱发结直肠癌机制的研究进展
- Author:
Bingfeng ZHENG
1
;
Zexu CHEN
;
Qi ZHENG
;
Jiansheng LIU
Author Information
1. 山西医科大学第一医院肝胆外科，太原 030001
- From:
Chinese Journal of Digestive Surgery
2020;19(5):559-562
- CountryChina
- Language:Chinese
-
Abstract:
Cholecystectomy is currently the most important surgical treatment for gallbladder disease, however, the complications of cholecystectomy, especially the occurrence of intestinal tumors has gradually aroused attention of scholars. In recent years, scholars have found that bile acid metabolism changes significantly after cholecystectomy, which may be the main cause of colorectal cancer induction, but the specific mechanism of colorectal cancer induced by cholecystectomy has not been clarified. In this article, the changes of bile acid metabolism after cholecystectomy (the size and composition of bile acid pool) and the mechanism of colorectal cancer induction after cholecystectomy were summarized and discussed based on the research progress at home and abroad, aiming at providing theoretical basis for the exploration of the prevention and treatment of colorectal cancer.
