Value of cancer-associated fibroblasts in the occurrence and development of pancreatic ductal adenocarcinoma
10.3760/cma.j.issn.1673-9752.2020.03.022
- VernacularTitle:肿瘤相关成纤维细胞在胰腺导管腺癌发生发展中的作用
- Author:
Shuang FAN
1
;
Jianguo ZHAO
;
Zhenxia WANG
Author Information
1. 内蒙古医科大学附属医院肝胆胰脾外科，呼和浩特 010050
- From:
Chinese Journal of Digestive Surgery
2020;19(3):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts (CAFs) are one of the most important cellular components of the tumor microenvironment in pancreatic ductal adenocarcinoma. CAFs acquire an activated phenotype via various cytokines, promote tumor proliferation and growth, accelerate invasion and metastasis, induce angiogenesis, and enhance chemical drug resistance. Therefore, studies on the interaction between CAFs and pancreatic ductal adenocarcinoma cells are expected to improve the diagnostic and therapeutic value of patients with pancreatic ductal adenocarcinoma from the perspective of tumor microenvironment.
