The pathogenesis of Kawasaki disease
10.3760/cma.j.issn.1673-4912.2020.09.002
- VernacularTitle:川崎病发生机制研究
- Author:
Chao NIU
1
;
Linlin WANG
;
Chang JIA
;
Maoping CHU
Author Information
1. 温州医科大学附属第二医院 育英儿童医院，温州 325027
- From:
Chinese Pediatric Emergency Medicine
2020;27(9):645-649
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease is an acute systemic vascular inflammatory syndrome, which is the main cause of acquired heart disease in children.It is most likely to cause serious complications such as coronary artery dilation, coronary artery aneurysm, and acute myocardial infarction.At present, there is no accurate conclusion about the etiology and pathogenic mechanism of Kawasaki disease.We performed this review to realize the etiology of Kawasaki disease regarding infectious pathogens, environmental factors, immune disorders and genetic tendencies.Meanwhile, this study will focus on the abnormal activation of the immune system, the up-regulated expression of inflammatory cytokines, the increased activity of metal matrix proteinases (MMPs), and vascular endothelial injury/vascular endothelial dysfunction to review the pathogenic mechanism of Kawasaki disease.
