The efficacy of hemoperfusion on treatment of Henoch-Sch?nlein purpura: a Meta-analysis
10.3760/cma.j.issn.1673-4912.2020.08.010
- VernacularTitle:血液灌流治疗过敏性紫癜疗效的Meta分析
- Author:
Zhongbin TAO
1
;
Yandong FENG
;
Juanli WANG
;
Jie WANG
;
Yaling YANG
;
Yongkang ZHOU
;
Bowen LI
;
Xiaoli YAN
;
Huili LIU
Author Information
1. 兰州大学第一医院儿科，兰州 730000
- From:
Chinese Pediatric Emergency Medicine
2020;27(8):609-613
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the treatment effect of hemoperfusion(HP) on Henoch-Sch?nlein purpura(HSP) outcomes.Methods:PubMed, Cochrane library, Web of science, Wanfang database, CNKI and CBM database were searched from inception to February 2020.Literatures of randomized controlled trials(RCTs) that investigated the effect of HP on HSP outcomes were included.Articles screening, data extraction and quality assessment were accomplished by two investigators independently, and statistical analyses were performed by RevMan 5.3.Results:Thirteen RCTs were included with 803 cases, of which, 397 cases were in the HP group while 406 cases were in the control group.The Meta-analysis revealed the HP group had less disappearing time of hematuresis or albuminuria[ MD=-2.77, 95% CI(-3.18, -2.36), P<0.001], relieving time of abdominal pain[ MD=-1.70, 95% CI(-2.17, -1.23), P<0.001], disappearing time of hematochezia[ MD=-1.54, 95% CI(-1.68, -1.40), P<0.001], and the length of hospital stay[ MD=-3.23, 95% CI(-3.60, -2.87), P<0.001] than the control group. Conclusion:The HP could shorten disappearing time of hematuresis or albuminuria, relieving time of abdominal pain, disappearing time of hematochezia, and the length of hospital stay of HSP.
