Dynamic changes of inflammatory factors and prognosis in acute infection children with glucose-6-phosphate dehydrogenase deficiency
10.3760/cma.j.issn.1673-4912.2020.06.015
- VernacularTitle:葡萄糖-6-磷酸脱氢酶缺陷急性重症感染患儿炎症因子动态变化与预后研究
- Author:
Wugui MO
1
;
Yupeng TANG
;
Rong WEI
;
Youjun XIE
;
Weizhen HUANG
;
Jun FU
;
Gongzhi LU
;
Zhirong MO
;
Jie ZHENG
Author Information
1. 广西壮族自治区妇幼保健院重症医学科，南宁 530003
- From:
Chinese Pediatric Emergency Medicine
2020;27(6):469-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the serum levels of inflammatory cytokines and prognosis in severe acute infection children with glucose-6-phosphate dehydrogenase(G6PD) deficiency.Methods:A total number of 160 children with severe acute infections admitted to PICU of Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital from June 2014 to December 2017 were selected as subjects in this study, including 80 children with G6PD deficiency(observation group) and 80 children without G6PD deficiency(control group). The changes of TNF-α, IL-6, IL-10 and CRP were dynamically monitored at 0-hour, 12-hour and 24-hour after admision, and the occurrences of sepsis, multiple organ dysfunction syndrome(MODS) were prospectively analyzed.Results:The levels of serum cytokines and CRP in the observation group were significantly higher than those in the control group at admission[TNF-α: (65.57±19.09) pg/ml vs.(46.53±20.34) pg/ml; IL-6: (98.90±29.02) pg/ml vs.(89.89±25.54) pg/ml; IL-10: (87.66±21.84) pg/ml vs.(76.34±19.01) pg/ml; CRP: (60.18±22.24) mg/L vs.(41.43±19.51) mg/L, respectively], and the differences between two groups were statistically significant( P<0.05). The levels of cytokines and CRP in the observation group were higher than those in the control group at 12 h and 24 h after treatment( P<0.01). Compared with the control group, the incidences of sepsis(82.50% vs 67.50%) and MODS(73.75% vs 58.75%) in the observation group increased, and the recovery rate(81.25% vs 92.50%) decreased, with statistical significance between two groups( P<0.05). Conclusion:Children with G6PD deficiency need to be paid more attention to inflammation, sepsis, MODS and the difficulty of treatment when they are infected.The potential mechanism may be related to oxidative stress.
