The effects of levetiracetam on bone metabolism and thyroid hormone levels in children with epilepsy for one year
10.3760/cma.j.issn.1673-4912.2020.05.010
- VernacularTitle:左乙拉西坦对癫痫患儿用药一年时骨代谢及甲状腺激素水平的影响
- Author:
Kaili SHI
1
;
Yunhong WU
;
Huimin ZHAO
;
Hong HAN
Author Information
1. 山西省儿童医院神经内科，太原 030013；广州市妇女儿童医疗中心神经内科 510623
- From:
Chinese Pediatric Emergency Medicine
2020;27(5):362-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of levetiracetam on bone metabolism and thyroid hormone levels in children with epilepsy.Methods:A total of 20 children with epilepsy first diagnosed in our hospital from July 2016 to June 2017 were selected as the treatment group, the other 20 children who received physical examination in the same period were selected as the control group.The treatment group was given oral LEV monotherapy for 12 months.The changes of bone metabolism indexes[blood calcium, blood phosphorus, alkaline phosphatase activities, osteocalcin, parathyroid hormone, 25-(OH)D], bone mineral density(BMD)and serum thyroid hormone(triiodothyronine, tetraiodothyronine, free triiodothyronine, free thyroxine, thyroid stimulating hormone) in the control group and the treatment group were detected before, 6 and 12 months after medication.Results:(1)There were no statistically significant differences in bone metabolism indexes and BMD between the control group and the treatment group before medication( P>0.05). The differences showed no statistically significant in bone metabolism indexes and BMD among different time points of treatment group( P>0.05). (2)There were no significant differences in thyroid hormone levels between the control group and the treatment group before medication( P>0.05). There were no significant differences in thyroid hormone levels among different time points of treatment group ( P>0.05). Conclusion:Levetiracetam has no significant effects on bone metabolism and thyroid hormone level in epileptic children.
