Clinical significance of common inflammatory factors in children with severe Mycoplasma pneumoniae pneumonia
10.3760/cma.j.issn.1673-4912.2020.05.012
- VernacularTitle:几种常见炎症因子在小儿重症肺炎支原体肺炎中的临床意义
- Author:
Min GUAN
1
;
Xuemei BAI
Author Information
1. 大连医科大学附属第二医院儿科 116027
- From:
Chinese Pediatric Emergency Medicine
2020;27(5):371-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical significance of soluble interleukin 2 receptor(sIL-2R), interleukin-6(IL-6), interleukin-8(IL-8), interleukin-10(IL-10), tumor necrosis factor-α(TNF-α), C-reactive protein(CRP) and procalcitonin(PCT) in the acute phase of severe Mycoplasma pneumoniae pneumonia(MPP).Methods:A total of 301 children with pneumonia admitted to the pediatric ward of the Second Affiliated Hospital of Dalian Medical University from September 2017 to December 2018 were selected and divided into severe MPP group(100 cases), mild MPP group(103 cases) and non MPP group(NMPP group, except for obvious bacterial infection, 98 cases were mainly mild viral infection). The serum levels of sIL-2R, IL-6, IL-8, IL-10, TNF-α, CRP and PCT were measured.Results:The serum levels of IL-6, PCT, CRP, IL-8, TNF-α and sIL-2R in severe MPP group were higher than those in mild MPP group and NMPP group( P<0.05). There was no significant difference in the serum level of IL-10 among the three groups( P>0.05). Receiver operating characteristic curve of inflammatory factors in severe MPP group indicated that IL-6 had the highest specificity(77.1%) and TNF-α had the highest sensitivity(85.0%). In severe MPP group, IL-6, PCT and CRP were the three inflammatory indexes with the largest area under receiver operating characteristic curve.IL-6 and PCT, IL-6 and CRP, PCT and CRP were positively correlated( r=0.277, 0.361, 0.538, respectively, P<0.05). Conclusion:The levels of IL-6, PCT, CRP, IL-8, TNF-α and sIL-2R in serum are important for the diagnosis, treatment and course evaluation of severe MPP.
