Effect of anemia on mortality in very low birth weight premature infants
10.3760/cma.j.cn211501-20191209-03645
- VernacularTitle:极低出生体质量早产儿合并贫血对死亡率的影响
- Author:
Qingjuan MENG
1
Author Information
1. 中国医科大学附属盛京医院第三新生儿病房，沈阳 110004
- From:
Chinese Journal of Practical Nursing
2020;36(22):1732-1735
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of anemia on mortality in very low-weight preterm infants.Methods:A total of 200 extremely low-weight preterm infants who were admitted to the neonatal intensive care unit from September 2016 to September 2018 were selected. Demographic and clinical data of maternal and premature babies were recorded. According to whether premature infants were associated with anemia, very low weight premature infants were divided into anemia group and non-anemia group. All variables of maternal and premature babies were compared between the two groups. All-cause deaths of preterm babies during hospitalization were used as dependent variables. Statistically significant variables were used as independent variables. Multivariate binary Logistic regression analysis of independent variables and dependent variables was performed.Results:Anemia group and non-anemia group included 64 cases and 136 cases respectively. In anemia group, the mean gestational age was (26.45 ± 2.32) weeks, the mean hematocrit was (37.72 ± 3.81)% and the mean hemoglobin was (12.81 ± 1.51) g/L; in non-anemia group, the data were (27.21 ± 2.21) weeks, (48.42 ± 5.61)% and (16.89 ± 2.12) g/L, respectively. There were significant differences in the above indexes ( t values were 10.23, 12.23, 8.51, P < 0.05 or 0.01). 43 cases (67.19%) in anemia group and 52 cases (38.24%, 52/136) in non-anemia group of Apgar score 1 min < 5 points. There was significant difference between the two groups in the above index ( χ2 value was 15.55, P < 0.01). In anemia group, there were 34, 26, 32 cases of the use of vasopressin, periventricular hemorrhage and death in the first 72 hours after birth, 41, 23, 50 cases in non-anemia group, there were significant differences between the two groups ( χ 2 values were 9.80, 13.23, 8.01, P < 0.01 or 0.05). The median of red blood cell transfusion was 2 days, 75 ml/kg from birth to the first blood transfusion in anemia group, and 7 days, 45 ml/kg from birth to the first blood transfusion in non-anemia group. There was statistical difference between the two groups in the above indexes ( U values were 482.2, 781.9, P < 0.05). In the first 72 hours after birth, the use of vasopressin, periventricular hemorrhage and anemia were independent risk factors ( OR values were 12.30, 13.40, 34.89, P < 0.05). Conclusions:If very low weight preterm infants are accompanied by anemia, the use of vasopressors in the first 72 hours after birth increases the risk of death from periventricular hemorrhage.
