Clinical Analysis of T4 Colorectal Cancer with Adhesion to Adjacent Organs.
- Author:
Mun Hyeong CHO
1
;
Jai Kyun JOO
;
Seong Yeob RYU
;
Hyeong Rok KIM
;
Dong Yi KIM
;
Young Jin KIM
Author Information
1. Division of Gastroenterologic Surgery, Department of Surgery, College of Medicine, Chonnam National University, Gwangju, Korea. kimyjin@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Lymph nodes;
Neoplasm metastasis
- MeSH:
Colorectal Neoplasms*;
Humans;
Jeollanam-do;
Korea;
Lymph Nodes;
Neoplasm Metastasis;
Peritoneum;
Prognosis;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Society of Coloproctology
2003;19(5):290-298
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: A colorectal cancer (CRC) is defined as T4 when the tumor directly invades other organs or structures and/or perforates the visceral peritoneum. The purpose of this study was to evaluate the results of a surgical approach and to determine the significant prognostic factors for tumor resectability and survival in patients with advanced T4 CRC. METHODS: A total of 61 patients with T4 CRC with adjacent organ adhesion, who received multivisceral resections at Chonnam University Hospital, Korea, between Jan. 1990 and Dec. 2001, were analyzed retrospectively. RESULTS: Cancer invasion to contiguous organs was present in 51 (83.6%) of the 61 patients who received a multivisceral resection and was absent in 10 (16.4%). Postoperative rates of complications and death were 22.9% and 4.9%, respectively, in the 61 patients. Lymph-node (LN) metastases were presented in 25 patients (41.0%). The 5-year survival rate (5 YSR) was 22.2% in patients with LN metastases, but was significantly higher (66.7%) in patients without LN metastases. The 5 YSRs for the 61 patients according to the AJCC cancer stage (TNM classification) were as follows: stage II (66.7%), stage III (46.4%), and stage IV (0%). CONCLUSIONS: T4 CRC without distant metastases requires multivisceral en-bloc resection of any organ or structure to which the primary tumor is adhered. The presence of LN metastases at the time of surgery is one of the significant factors with a poor prognosis in T4 CRC.
