Effect of interleukin-6/signal transducer and activator of transcription 3 signaling pathway on heart repair
10.3760/cma.j.cn101070-20200419-00682
- VernacularTitle:白细胞介素-6/信号转导及转录活化因子3信号传导通路在心脏修复中的作用
- Author:
Shu NIE
1
;
Jinxin ZHANG
;
Yanyan HAN
Author Information
1. 吉林大学第一医院小儿心血管科，长春 130021
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(23):1838-1840
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-6 (IL-6) is involved in the repair of various tissues.As a key transcription factor in IL-6 pathway, signal transducer and activator of transcription 3(STAT3) is required for heart protection.By inducing STAT3 activation, IL-6 signaling pathway could repair the cardiac damage in the healing process of many kinds of heart diseases, including cardiac injury, myocarditis and heart failure.Therefore, researches on the effect of IL-6/STAT3 pathway on heart repair has potential therapeutic implications for heart diseases.
