An assessment of diagnostic value and health economics of nucleic acid-based detection in infectious diseases in children
10.3760/cma.j.cn101070-20201009-01594
- VernacularTitle:核酸分子检测技术在儿童感染性疾病中的诊断价值及卫生经济学评价
- Author:
Qing CAO
1
;
Qiaozhen ZHANG
;
Yue ZHU
;
Nan SHEN
Author Information
1. 上海交通大学医学院附属上海儿童医学中心感染科 200127
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(22):1689-1693
- CountryChina
- Language:Chinese
-
Abstract:
Infectious diseases is one of the leading causes of disability and death in children worldwide.Rapid, accurate and early detection of causative pathogens can contribute to timely treatment and diagnosis and may improve the prognosis of children with infectious disease.The continuous improvement of techniques in molecular biology, especially nucleic acid-based detection, have driven the development of accurate identification of the pathogens.Molecular diagnostic tests based on the polymerase chain reaction, alternative nucleic acid amplification, gene microarray, next-generation sequencing as well as clustered regularly interspaced short palindromic repeats-based technologies have gradually become important auxiliary tools for screening infectious pathogen due to their depth and accuracy.In this paper, several nucleic acid-based detection technologies are compared in order to constitute an appropriate diagnostic strategy for the detection of infectious pathogens.
