The role of basophils in asthma
10.3760/cma.j.cn101070-20201019-01637
- VernacularTitle:嗜碱性粒细胞在支气管哮喘中的作用
- Author:
Wenwei ZHONG
1
;
Jingyang LI
;
Mengxue CHEN
;
Shasha BAI
;
Yutong GU
;
Jianhua ZHANG
Author Information
1. 上海交通大学医学院附属新华医院儿呼吸内科 200092
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(21):1608-1609
- CountryChina
- Language:Chinese
-
Abstract:
Basophils have been neglected for a long time as an immune cell.Recently, it gained respect because of its important role in helper T lymphocytes(Th)2 immune response.Basophils are involved in the pathogenesis of bronchial asthma through a variety of possible mechanisms.Basophils can act as initiators initiate and establish Th2 immune response by interacting with dendritic cells; basophils can act as immune regulators, regulate immune cell functions such as type 2 innate lymphoid cells by secreting cytokines such as interleukin 4 to consolidate allergic inflammation; basophils can also act as immune effectors participate in allergic airway inflammation through IgE-depended and non IgE-depended activation.In addition, clinical research is focused on the usage of basophil activation status as possible biomarker in predicting the outcome of allergic disease therapy, which is of great clinic value in individualized management of asthma.
