Non-biological artificial liver technology in the treatment of early liver allograft dysfunction in 2 children with liver transplantation
10.3760/cma.j.cn101070-20190305-00158
- VernacularTitle:非生物型人工肝技术应用于儿童肝移植术后移植物肝脏失功能2例
- Author:
Sijuan SUN
1
;
Jian ZHANG
;
Yueling XI
;
Yunqing ZHOU
;
Diqi ZHU
;
Hong REN
;
Ying WANG
;
Juan QIAN
Author Information
1. 上海交通大学医学院附属上海儿童医学中心重症医学科 200127
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(19):1511-1513
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data of 2 children with early graft liver dysfunction (EAD) admitted to the Pediatric Intensive Care Unit, Shanghai Children′s Medical Center, Shanghai Jiaotong University School of Medicine were retrospectively analyzed to discussed the therapeutic significance of non-biological artificial liver technology, such as intermittent plasma exchange (PE) combined with continuous veno-venous hemodiafiltration (CVVHDF) in children with EAD.Case 1 was suffering from biliary atresia, and case 2 was suffering from Niemann-Pick disease.Graft liver dysfunction and multiple organ dysfunction occurred in 2 children after liver transplantation.PE and CVVHDF were initiated early in the first two days after liver transplantation.After one-week therapy with intermittent PE plus CVVHDF, acute multiple organ dysfunction were reversed with liver function remarkably improved in the 2 cases.Therefore non-biological artificial liver technique can be tried after liver transplantation in children.This technique contributes to the recovery of liver function and can improve the secondary multi-organ insufficiency.
