Progress in diagnosis and treatment of children with primary membranous nephropathy
10.3760/cma.j.cn101070-20200731-01273
- VernacularTitle:儿童原发膜性肾病诊治进展
- Author:
Fang WANG
1
;
Zhonghua WANG
Author Information
1. 北京大学第一医院儿科 100034
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(17):1310-1312
- CountryChina
- Language:Chinese
-
Abstract:
As an immune complex-mediated renal disease, membranous nephropathy(MN) can occur at all ages.Primary membranous nephropathy(PMN) can lead to end-stage renal disease although it is not common in children.Antibodies against M-type phospholipase A2 receptor / thrombospondin type-1 domain-containing 7A are initially detected in adult PMN, and also present in children and adolescents with PMN.These antibodies serve as useful biomarkers to diagnose and monitor PMN.Rituximab has been successfully used in the treatment of adult PMN, and is possibly effective in children with PMN as well.
