Advances in diagnosis and treatment of children with anti-neutrophil cytoplasmic antibodies - associated vasculitis
10.3760/cma.j.cn101070-20200807-01312
- VernacularTitle:儿童抗中性粒细胞胞质抗体相关性血管炎的诊治进展
- Author:
Lizhi CHEN
1
;
Xiaoyun JIANG
Author Information
1. 中山大学附属第一医院儿科，广州 510080
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(17):1313-1319
- CountryChina
- Language:Chinese
-
Abstract:
Anti-neutrophil cytoplasmic antibodies(ANCA)associated vasculitis(AAV)is a kind of necroti-zing vasculitis with oligomeric or non-immune complex deposits, mainly involving small to medium vessels, and multiple organs are also frequently involved.AAV in children remains rare.Renal involvement in children is more severe than that in adults.The severity of renal lesions and disease activity are important predictors of long-term outcomes of AAV in children.Newer immunosuppressive agents and plasma exchange have further improved the prognosis of AAV in recent years.Early diagnosis, accurate disease state evaluation, and the development of reasonable individualized treatment plans are of great clinical significance for improving the prognosis of children with AAV.In this paper, the pathogenesis, clinical manifestations, diagnosis and treatment of AAV in children were described in order to improve the level of diagnosis and treatment of AAV in children.
