Progress in pathogenic genes of focal segmental glomerulosclerosis
10.3760/cma.j.cn101070-20190808-00724
- VernacularTitle:局灶节段性肾小球硬化致病基因研究进展
- Author:
Heyan WU
1
;
Ren WANG
;
Meiqiu WANG
;
Yingchao PENG
;
Chunlin GAO
;
Zhengkun XIA
Author Information
1. 南方医科大学第一临床医学院（东部战区总医院）儿科，南京 210002
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(17):1358-1360
- CountryChina
- Language:Chinese
-
Abstract:
Focal segmental glomerulosclerosis (FSGS) is characterized by the fusion of foot processes of podocytes, and can lead to end-stage kidney disease in children.The pathogenesis of FSGS has not been fully clarified, but more than 30 pathogenic genes have been identified in FSGS patients in recent years with the development of molecular genetics.These findings prove that the destruction of the structure and function of podocytes plays a role in the pathogenesis of FSGS.In this paper, the research progress of common pathogenic genes of FSGS was reviewed.
