Clinical feature, diagnosis and treatment of Wolfram syndrome
10.3760/cma.j.cn101070-20190616-00541
- VernacularTitle:Wolfram综合征的临床特征、诊断及治疗
- Author:
Lu YU
1
;
Yujia LIU
;
Yue QIU
;
Dan HAN
;
Guixia WANG
Author Information
1. 吉林大学白求恩第一医院内分泌代谢科，长春 130021
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(15):1195-1198
- CountryChina
- Language:Chinese
-
Abstract:
Wolfram syndrome(WS) is a rare autosomal recessive neurodegenerative disease characterized by diabetes insipidus, onset diabetes mellitus, optic atrophy and sensorineural hearing loss.The syndrome is mainly caused by mutations in the WFS1 gene, and another causative gene, CISD2 gene is responsible for Wolfram syndrome 2 with different phenotypes.The prognosis of WS is poor, 60% of patients die before the age of 35 years old.Currently, there are no effective treatments to delay or reverse the progression of WS, standardized clinical monitoring and supportive care can help alleviate the debilitating symptoms of patients and improve their quality of life.This article reviews the pathogenesis, clinical feature, diagnosis and new treatments of WS.
