Malignancy-associated hemophagocytic lymphohistiocytosis in children
10.3760/cma.j.cn101070-20200717-01200
- VernacularTitle:儿童恶性肿瘤相关性噬血细胞综合征
- Author:
Fen ZHOU
1
;
Tiantian YIN
Author Information
1. 华中科技大学同济医学院附属协和医院儿科，武汉 430020
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(15):1134-1137
- CountryChina
- Language:Chinese
-
Abstract:
Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is a highly stimulated and defective inflammatory response caused by genetic inheritance or acquired immune regulation abnormalities.Malignancy-associated HLH can be secondary to lymphoma, leukemia, etc.HLH-directed or malignancy-directed combination chemotherapy is the main regimen and the prognosis is poor.Now the pathogenesis, clinical manifestations, diagnosis and treatment of malignancy-associated HLH will be reviewed in children, in order to increase understanding of the disease.
