Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the 13C Breath Test.
- Author:
Takashi NONAKA
1
;
Yusuke SEKINO
;
Hiroshi IIDA
;
Eiji YAMADA
;
Hidenori OHKUBO
;
Eiji SAKAI
;
Takuma HIGURASHI
;
Kunihiro HOSONO
;
Hiroki ENDO
;
Tomoko KOIDE
;
Hirokazu TAKAHASHI
;
Koji FUJITA
;
Masato YONEDA
;
Ayumu GOTO
;
Akihiko KUSAKABE
;
Noritoshi KOBAYASHI
;
Eiji GOTOH
;
Shin MAEDA
;
Atsushi NAKAJIMA
;
Chihiro NOSAKA
;
Masahiko INAMORI
Author Information
1. Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Breath tests;
Gastric emptying;
Sitagliptin
- MeSH:
Breath Tests;
Cross-Over Studies;
Eating;
Gastric Emptying;
Gastrointestinal Motility;
Humans;
Incretins;
Male;
Meals;
Pyrazines;
Triazoles;
Sitagliptin Phosphate
- From:Journal of Neurogastroenterology and Motility
2013;19(2):227-232
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the 13C-acetic acid breath test. METHODS: Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg 13C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (beta and kappa), calculated by using the 13CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically. RESULTS: No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or beta and kappa, were observed between the 2 test conditions. CONCLUSIONS: The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.
