Surgical treatment of epilepsy in children with definite epileptogenic lesion under 1 year old
10.3760/cma.j.cn101070-20200424-00724
- VernacularTitle:1岁以下存在明确致痫病灶儿童癫痫的手术治疗
- Author:
Hao YU
1
;
Lixin CAI
;
Qingzhu LIU
;
Chang LIU
;
Yu SUN
;
Xiaoyan LIU
;
Shuang WANG
;
Taoyun JI
;
Ruofan WANG
;
Yuwu JIANG
Author Information
1. 北京大学第一医院儿童癫痫中心 100034
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(14):1081-1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics, surgical methods, complications and prognosis of children younger than 1 year old who had definite epileptogenic lesions under 1 year old.Methods:A total of 14 children with definite epileptogenic lesions and underwent radical surgery in Pediatric Epilepsy Center of Peking University First Hospital from March 2017 to July 2019 were selected.Their clinical data including operation age, course of disease, etiology, physical examinations, seizure types, seizure frequency, features of interictal electrocorticography(EEG), surgical methods, antiepileptic drugs, and pathology were collected and analyzed.Postoperative efficacy was eva-luated using Engel grading.The Griffiths neurodevelopmental scale and the Peabody motor developmental scale were used to assess motor neurodevelopment.Results:The operation age of 14 children was 119 to 358 days (median: 281 days), and the course of disease ranged from 119 to 352 days (median: 266 days). The age of onset was from 0 to 135 days was (median: 7.5 days), and the postoperative follow-up time was 0.5-2.0 years(median: 1.5 years). None of the patients had seizure recurrence at the last follow-up.During the follow-up period, 1 patient had recurrence, but deve-loped no seizures anymore after drug administration.Cognitive and motor functions improved during follow-up in all children.All the children had no serious complications such as postoperative infection and hydrocephalus.Conclusions:Young children with definite epileptogenic lesions have an early onset of seizures, which has a great influence on development.Multidisciplinary preoperative evaluation shows that surgery is a safe way to terminate progression of seizures, thus helping children to well develop and reducing the use of antiepileptic drugs.
