Research progress on the effects of fibroblast growth factor 10 signal transduction on lung development and disease
10.3760/cma.j.cn101070-20190506-00378
- VernacularTitle:成纤维细胞生长因子10信号转导对肺发育及肺部疾病影响的研究进展
- Author:
Limin WANG
1
;
Linlin DU
;
Chaobin SHEN
Author Information
1. 蚌埠医学院研究生院，安徽 蚌埠 233000
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(14):1117-1120
- CountryChina
- Language:Chinese
-
Abstract:
Congenital abnormalities of the neonatal lung structure can easily cause childhood lung diseases and increase the susceptibility to chronic lung diseases in adulthood.Fibroblast growth factor 10(FGF10) regulates structu-ral morphology, cellular differentiation, and damage response at multiple stages of lung development.FGF10 deficiency in the formation stage of bronchial branches will lead to neonatal lung disease.In other words, congenital airway abnorma-lities caused by gene mutations in the fgf10 cause increase the risk of developing chronic lung diseases in adulthood.FGF10 also maintains lung precursor cell lines and promotes proliferation and differentiation of alveolar typeⅡ cells after lung injury.In this article, the cellular and molecular mechanisms of FGF10 associated with various lung diseases were reviewed, including bronchopulmonary dysplasia in extremely premature infants, cystic lung fibrosis in children, and chronic lung diseases in adults, so as to offer help for the development of new therapeutic strategies for respiratory diseases.
