Application value of acoustic radiation force impulse elastography in diagnosis of biliary atresia
10.3760/cma.j.cn101070-20190411-00304
- VernacularTitle:声辐射力脉冲成像技术对胆道闭锁患儿的临床诊断价值
- Author:
Xia WANG
1
;
Qingnan YANG
;
Lijuan XIE
;
Zhenjuan HE
;
Yan CHEN
;
Hongping XIA
;
Tianwen ZHU
;
Shengli GU
;
Yongjun ZHANG
Author Information
1. 上海交通大学医学院附属新华医院新生儿科 200092
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(12):922-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the value of acoustic radiation force impulse (ARFI) elastography in the diagnosis of children with biliary atresia.Methods:A prospective survey of infants with hepatitis syndrome and hyperbi-lirubinemia in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from January 2017 to December 2018 was performed.The children with hepatitis syndrome were divided into the biliary atresia group( n=45) and non- biliary atresia group( n=30). Thirty children with hyperbilirubinemia were selected as the control group.Shear wave speed (SWS) of all infants was collected by ARFI ultrasound and compared among 3 groups.Receiver ope-rating characteristic curve(ROC curve) was used to analyze the optimal threshold value for SWS in the diagnosis of biliary atresia. Results:The mean SWS values in the biliary atresia group, non-biliary atresia group and the control group were (1.79±0.29) m/s, (1.26±0.12) m/s and (1.08±0.06) m/s, respectively.Compared with the control group, the mean SWS values in the biliary atresia group and non-biliary atresia group were significantly higher ( t=165.43, 15.75, all P<0.05). The mean SWS value in the non-biliary atresia group was significantly lower than that in the biliary atresia group ( t=90.27, P<0.05). With the non-biliary atresia group as reference, the area under the ROC curve of SWS for diagnosis of biliary atresia was 0.98(95% CI: 0.95-1.00), the optimal threshold was 1.45 m/s, and the sensitivity and specificity were 88.9% and 96.7%, respectively. Conclusions:Rapid non-invasive ARFI elastography is effective in the diagnosis of biliary atresia, and thus has important value for early diagnosis and treatment in clinical practice.
