Study progress of chronic granulomatous disease in children
10.3760/cma.j.cn101070-20190301-00147
- VernacularTitle:儿童慢性肉芽肿病研究进展
- Author:
Dingle YU
1
;
Wenjian WANG
;
Yuejie ZHENG
;
Kunling SHEN
Author Information
1. 深圳市儿童医院呼吸科，广东 深圳 518038
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(11):877-880
- CountryChina
- Language:Chinese
-
Abstract:
Chronic granulomatous disease(CGD)is a rare primary immunodeficiency disease with X-linked or autosomal pattern of inheritance, which belongs to monogenic disorders, mainly manifested in repeated infection, granuloma formation caused by inflammatory response disorder and other inflammatory diseases.Detection of neutrophil respiratory burst function can screen the disease, and gene sequence analysis can identify the pathogenic genes.Now, the latest research on gene therapy was updated, and the clinical manifestations, diagnosis, routine treatment and hemato-poietic stem cell transplantation(HSCT)were summarized in order to strengthen the clinicians′ understanding of CGD.
