Primary immunodeficiency diseases susceptible to mycobacteria in children
10.3760/cma.j.cn101070-20200220-00205
- VernacularTitle:分枝杆菌感染相关儿童原发性免疫缺陷病
- Author:
Qingqin YIN
1
;
Jianxin HE
;
Baoping XU
Author Information
1. 国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心,北京 100045
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(10):779-782
- CountryChina
- Language:Chinese
-
Abstract:
Primary immunodeficiency diseases (PIDs) refer to immune function decrease and deficiency or immune regulation function imbalance resulted from immune cell or immunomolecular defects caused by single gene mutation.Children with PIDs are prone to develop infectious diseases.Because the immune mechanisms of hosts infected by different pathogens infecting vary, different types of PIDs are relatively susceptible to different pathogens.A number of studies have indicated that some PIDs children are more likely to develop Bacilles Calmétte-Guerin infection, severe tuberculosis and non- Tuberculous mycobacteria severe infection.In this review, several major primary immunodeficiency diseases closely related to the susceptibility of mycobacteria were summarized, including chronic granulomatous disease, severe combined immunodeficiency disease, mendelian susceptibility to mycobacterial disease, and high IgM syndrome, in order to provide a theoretical basis for early identification of such diseases.