Progress and challenge in tuberculosis vaccine research
10.3760/cma.j.cn101070-20200226-00255
- VernacularTitle:结核病疫苗研发进展及挑战
- Author:
Jieqiong LI
1
;
Adong SHEN
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院，北京市儿科研究所，儿科学国家重点学科，国家呼吸系统疾病临床医学研究中心，儿科重大疾病研究教育部重点实验室，儿童呼吸道感染性疾病研究北京市重点实验室，北京 100045
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(10):721-725
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis(TB) is a serious threat to children′s health.The World Health Organization reported that there were almost 10 million new TB cases(including 1.12 million pediatric patients) and 1 240 000 deaths(173 000 were children) globally in 2018." Find.Treat.All.#End TB" points out that an effective vaccination is the most effective method for the control of infectious diseases.It is difficult to diagnose TB in children in the early stage due to atypical clinical symptoms of TB, leading to treatment delay.Therefore, vaccination is essential for the prevention of pediatric TB.However, the problems of limited immune duration, unclear protective effect and increasing the risk of BCG disease existing in Bacillus Calmette-Guerin(BCG), the only TB vaccine widely used in the world, necessitate the development of new vaccines.The progress in and challenges of research on TB vaccines were reviewed in this article, which helps provide reference for the development of new vaccines and seeking solutions of above problems.
