Relationship between tuberculosis and microbiota
10.3760/cma.j.cn101070-20200217-00179
- VernacularTitle:结核病和微生物菌群的关系
- Author:
Jiabin PEI
1
;
Yuyuan YANG
;
Xintong ZHOU
;
Ge HU
;
Xuehan WANG
;
Yong GUO
;
Kaixia MI
Author Information
1. 北京农学院动物科学技术学院 102206
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(10):775-779
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis(TB) caused by the Mycobacterium tuberculosis(Mtb) is a worldwide public health threat.Microbiota in body affects human health and is involved in human diseases, and its clinical importance is begi-nning to be understood.In this review, studies on the relationship between the establishment of Mtb infection and microbiota as well as the development and antibiotic treatment of Mtb infection were discussed.Studies have shown that: (1) microbiota influences the establishment of Mtb infection; (2) co-infection of Helicobacter pylori alters susceptibility to Mtb infection and progression of active TB; (3) microbiota influences the progression of TB by regulating the nutritio-nal, metabolic and immune status of the host; (4) susceptibility to reinfection increases in TB patients treated with antibiotics, possibly due to T-cell epitope depletion of common intestinal non-Mtb Mycobacterium, the effects of antibio-tics are long-term in patients; (5) the occurrence of childhood TB is age-related and many factors such as co-infection and vaccine inoculation increase risk.An in-depth study of the relationship between the microbiota and TB will provide a new perspective on the prevention of TB.
