Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats.
10.4142/jvs.2015.16.2.157
- Author:
Fan YANG
1
;
Jijun KANG
;
Fang YANG
;
Zhensheng ZHAO
;
Tao KONG
;
Zhenling ZENG
Author Information
1. Laboratory of Veterinary Pharmacology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
enrofloxacin;
lung-targeting;
microsphere;
preparation;
tissue distribution
- MeSH:
Animals;
Anti-Bacterial Agents/*adverse effects;
Drug Delivery Systems/instrumentation/*methods;
Female;
Fluoroquinolones/*adverse effects;
Half-Life;
Humans;
Injections, Intravenous;
Lung/*drug effects;
Male;
*Microspheres;
Rats;
Rats, Sprague-Dawley;
Tissue Distribution
- From:Journal of Veterinary Science
2015;16(2):157-164
- CountryRepublic of Korea
- Language:English
-
Abstract:
New enrofloxacin microspheres were formulated, and their physical properties, lung-targeting ability, and tissue distribution in rats were examined. The microspheres had a regular and round shape. The mean diameter was 10.06 microm, and the diameter of 89.93% of all microspheres ranged from 7.0 microm to 30.0 microm. Tissue distribution of the microspheres was evaluated along with a conventional enrofloxacin preparation after a single intravenous injection (7.5 mg of enrofloxacin/kg bw). The results showed that the elimination half-life (t(1/2beta)) of enrofloxacin from lung was prolonged from 7.94 h for the conventional enrofloxacin to 13.28 h for the microspheres. Area under the lung concentration versus time curve from 0 h to infinity (AUC(0-infinity)) was increased from 11.66 h.microg/g to 508.00 h.microg/g. The peak concentration (Cmax) in lung was increased from 5.95 microg/g to 93.36 microg/g. Three lung-targeting parameters were further assessed and showed that the microspheres had remarkable lung-targeting capabilities.
