Strengthening the management of vitamin D deficiency/insufficiency and its associated hyperparathyroidism in breast cancer patients
10.3760/cma.j.cn.115807-20200611-00178
- VernacularTitle:关注乳腺癌患者维生素D缺乏/不足及相关甲状旁腺功能亢进症的防治
- Author:
Lingquan KONG
1
;
Juan WU
;
Shen TIAN
;
Hao LI
;
Hongyuan LI
;
Guosheng REN
;
Kainan WU
Author Information
1. 重庆医科大学附属第一医院内分泌乳腺外科 400016
- From:Chinese Journal of Endocrine Surgery
2020;14(5):353-357
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D deficiency/insufficiency has become a worldwide public health problem, especially in breast cancer patients. Vitamin D is a fat-soluble vitamin necessary for human body, which has important physiological functions such as regulating calcium and phosphorus metabolism and affecting cell proliferation and differentiation. Vitamin D deficiency/insufficiency is closely related to the occurrence of bone diseases and various extra-bone diseases, and is also a risk factor for the occurrence, development and poor prognosis of breast cancer. Vitamin D deficiency/insufficiency and low blood calcium are the main cause of enhanced parathyroid function or secondary hyperparathyroidism, but are often overlooked due to the absence of early clinical manifestations. Bone problems of breast cancer patients are more obvious than those of general population because of the systemic treatment such as chemotherapy and endocrine therapy and changes in menstrual state, and vitamin D deficiency and secondary hyperparathyroidism will further aggravate their bone health problems. Therefore, it is necessary to strengthen the monitoring of blood calcium, parathyroid hormone and bone metabolism indicators in breast cancer patients, so as to make targeted supplementation of vitamin D and calcium. We should pay attention to the prevention and treatment of vitamin D deficiency/insufficiency associated hyperparathyroidism and bone health problems to improve the quality of life and prognosis of patients.
