Correlation between SLC2A2 gene polymorphism and metformin efficacy in type 2 diabetes mellitus
10.3760/cma.j.issn.115807-20200130-00019
- VernacularTitle:SLC2A2基因多态性与2型糖尿病患者二甲双胍疗效的相关性
- Author:
Yang LIU
1
;
Jing YANG
;
Jinhua YIN
Author Information
1. 山西医科大学第一医院内分泌科，太原 030001
- From:Chinese Journal of Endocrine Surgery
2020;14(3):223-227
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between SLC2A2 rs5393, rs5400 loci gene polymorphism and metformin efficacy in patients with type 2 diabetes mellitus (T2DM) .Methods:From Jan. 2016 to Apr. 2019, 90 T2DM patients and 90 healthy persons were selected as the subjects. The frequencies of SLC2A2 rs5393 and rs5400 loci gene polymorphisms were detected by PCR restriction fragment length polymorphism (PCR-RELP) method. Patients with T2DM were treated with metformin and followed up for 90 days. The relationship between metformin efficacy and genotypes was analyzed.Results:The genotypes of SLC2A2 rs5393 and rs5400 in the control group and T2DM group were in accordance with Hardy Weinberg equilibrium law. Compared with the control group, the ratios of AC type and CC type at rs5393 locus in T2DM group was significantly higher ( P<0.05) , and the frequencies of CT type and TT type at rs5400 locus were significantly higher ( P<0.05) . There was no significant difference in the levels of FPG, 2 h PBG and HbA1c of AA type, AC type and CC type at rs5393 locus before treatment ( P>0.05) , after metformin treatment, FPG, 2hPBG and HbA1c of patients with AC type and CC type were lower than those with AA type ( P<0.05) , and the decreases of FPG and HbA1c in CC type were lower than those in AC type ( P<0.05) . There was no significant difference in the levels of FPG, 2hPBG and HbA1c of CC type, CT type and TT type at rs5400 locus before treatment ( P>0.05) . After metformin treatment, FPG, 2 h PBG and HbA1c of patients with CT type and TT type were lower than those with CC type ( P<0.05) , and the decreases of FPG and HbA1c in TT type were lower than those in CT type ( P<0.05) . Conclusion:T2DM patients with AA type at rs5393 locus and CC type at rs5400 locus of SLC2A2 gene polymorphism loci are sensitive to metformin and has good hypoglycemic effect.
