Identification and clinical significance of corynebacterium from abscess in granulomatous mastitis
10.3760/cma.j.issn.115807-20190617-00113
- VernacularTitle:肉芽肿性乳腺炎棒状杆菌检测对临床用药的指导意义
- Author:
Huixian CHEN
1
;
Haijing YU
;
Simei XIE
;
Zhenqiang LIAN
;
Jian MA
;
Xiaoping MU
;
Caixia WU
;
Limei ZHAO
;
Qi WANG
Author Information
1. 广东省妇幼保健院乳腺病中心 511400（现在广东省第二人民医院普通外科 510317）
- From:
Chinese Journal of Endocrine Surgery
2020;14(2):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To make the early clinical antibiotic regimen by finding out the infection of corynebacterium in the pus of patients with granulomatous mastitis in the early stage.Methods:A total of 42 patients who were diagnosed and treated in the Breast Center of Guangdong Maternal and Child Health Hospital from Jun. 2016 to Mar. 2017 with complete follow-up data were retrospectively analyzed. PCR method was used to detect corynebacterium in the patients’ pus. Patients in the positive group were treated with antibiotics alone, antibiotics + hormones and hormones alone, while patients in the negative group were treated with antibiotics + hormones and hormones alone. The postoperative recurrence rate and cure rate of different groups of patients were observed.Results:The antibiotic regimen for granulomatous mastitis in patients with corynebacterium infection included a combination of short-acting levofloxacin and azithromycin and long-acting anti-mycobacterium drugs. Among the 42 patients in the subgroup, 21 patients were confirmed positive for corynebacterium by PCR detection of pus, and the postoperative recurrence rate was 23.5%. There was a statistically significant difference between the antibiotic group, the antibiotic + hormone group and the hormone group in treatment of granulomatous mastitis infected with corynebacterium ( χ2=5.494, P=0.036) . PCR detection shouwed corynebacterium negative in 21 cases, and postoperative recurrence rate of 16.7%. No statistically significant difference in efficacy was found between antibiotic + hormone group and hormone only group for GM patients without bacterial infection ( χ2=1.129, P=0.719) . Conclusion:Early detection of corynebacterium infection in GM patients is significant for clinical guidance of the application of lipophilic antibiotics.
