The expression and clinical significance of miR-143-3p in papillary thyroid cancer
10.3760/cma.j.issn.1674-6090.2020.01.007
- VernacularTitle:miR-143在甲状腺乳头状癌中的表达及临床意义
- Author:
Guibin ZHENG
1
;
Shujian WEI
;
Guochang WU
;
Chi MA
;
Haiqing SUN
;
Huanjie CHEN
;
Xiangfeng LIN
;
Hui ZHAO
;
Haitao ZHENG
Author Information
1. 青岛大学附属烟台毓璜顶医院甲状腺外科 264000
- From:Chinese Journal of Endocrine Surgery
2020;14(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression and clinical significance of miR-143 in papillary thyroid cancer (PTC) .Methods:Tumor samples and adjacent tissues from 52 patients with PTC were obtained from Jan. 1st, 2018 to Mar. 31st, 2018 in Thyroid Surgery Department of the Affiliated Yantai Yuhuangding Hospital of Qingdao University. Quantitative reverse-transcriptase PCR (RT-qPCR) was used to measure the expression of miR-143 in those subjects. In addition, the relationship between the expression levels of miR-143 and the clinicopathological characteristics was analyzed.Results:RT-qPCR indicated that the expression of miR-143 was down-regulated in PTC, which was significantly lower than that in adjacent tissues ( t=-21.39, 95% CI: 18.20-15.07, P<0.001) . Low expression of miR-143 was related to the number of lymph node metastasis ≥3 in central compartment ( t=10.13, P=0.012) and lateral neck lymph node metastasis ( t=-4.67, P<0.001) . Conclusion:Downregulation of miR-143 in PTC is linked to the metastasis of PTC and may be a potential target for therapeutic intervention.
