The role of elevated blood amylase in the assessment of diabetic ketoacidosis
10.3760/cma.j.issn.1671-0282.2020.05.018
- VernacularTitle:血淀粉酶升高在糖尿病酮症酸中毒病情评估中的作用
- Author:
Yanxia GAO
1
;
Yanan WANG
;
Ding YUAN
;
Yibo WANG
;
Yi LI
;
Linlin HOU
;
Pei SUN
;
Yan ZHANG
;
Guoyu DUAN
;
Zhigao XU
Author Information
1. 郑州大学第一附属医院郑东院区急救中心 450052
- From:
Chinese Journal of Emergency Medicine
2020;29(5):707-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate therole of serum amylase elevation in the evaluation of diabetic ketoacidosis (DKA) patients and the related factors affecting serum amylase (AMS) levels in patients with diabetic ketoacidosis.Methods:A total of 249 patients with DKA who were admitted to the First Affiliated Hospital of Zhengzhou University from November 2011 to August 2018 were selected for this retrospective study. The patients were divided into the normal group ( n=176) and the elevated group ( n=73) according to the AMS level measured by fasting venous blood samples. The enumeration data such as sex, type of DM, diabetic vascular complications, number of deaths, number of ICU monitoring, and number of acute pancreatitis (AP) after discharge were analyzed by chi-square test or Fisher test, and the measurement data such as age, pH, HbA1c, CO 2CP, Ca 2+, BUN, and Scr were analyzed by independent sample t test to compare the difference between the two groups. Results:The intensive care unit (ICU) monitoring rate was 50.7%, the median length of stay in ICU was 4 days, the median length of hospital stay was 14 days, and the median treatment cost was 28 000 yuan, which were higher in the elevated group than those in the normal group ( P<0.05). There were no significant differences in mortality, AP during hospitalization, and the probability of AP after discharge between the elevated group and the normal group ( P>0.05). The duration of diabetes, the number of previous DKA, the incidence of diabetic vascular complications, HbA1c, pH, BUN, and Scr in the elevated group were all higher than those in the normal group ( P<0.01 or P<0.05). Conclusions:DKA patients with elevated AMS are more likely to be admitted to ICU, and the length of stay in ICU, total length of hospital stay and total cost of treatment are all increased. Where as the overall mortality rate during hospitalization and the likelihood of AP after discharge are not increased.
