Comparison of effects of metaraminol and norepinephrine on elderly patients with septic shock
10.3760/cma.j.issn.1671-0282.2020022.008-2
- VernacularTitle:间羟胺与去甲肾上腺素对老年脓毒性休克患者疗效的比较
- Author:
Linqin MA
1
;
Jiaqi ZHANG
;
Yi LIU
;
Caijun WU
Author Information
1. 北京中医药大学脓毒症研究所, 北京 100700
- From:
Chinese Journal of Emergency Medicine
2020;29(4):547-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effect of metaraminol and norepinephrine (NA) on elderly patients with septic shock.Methods:In this multicenter prospective cohort study elderly patients with septic shock were divided into the metaraminol group ( n=100) and NA group ( n=100). The 28-day survival and average hospital stay, the hemodynamics and renal function of the patients were observed. Results:The average hospital stay in the metaraminol group was lower than that in the NA group ( P < 0.05). Blood pressure, heart rate, arterial lactate, B-type natriuretic peptide, left ventricular ejection fraction and 28-day survival had no significant differences between the two groups (all P > 0.05). The average urine output at day 3 and 7 after the administration of vasopressor in the metaraminol group were higher than those in the NA group (all P< 0.05), blood urea nitrogen at day 3, 7 and 14 after the administration of vasopressor in the metaraminol group were lower than those in the NA group (all P < 0.05), and the creatinine at day 3, 7 and 14 after the administration of vasopressor and the rate of renal replacement therapy in the metaraminol group were lower than those in the NA group (all P < 0.05). Conclusions:Metaraminol has similar effect to norepinephrine in improving 28-day survival and hemodynamics of elderly patients with septic shock, but is superior to norepinephrine in reducing the average hospital stay and protecting renal function.
