Orthogonal test method to optimize the extraction process of Xiaoaiping capsules
10.3760/cma.j.cn115398-20200114-00095
- VernacularTitle:正交试验法优选消癌平胶囊提取工艺
- Author:
Kaiyong DENG
1
;
Fu LIU
;
Meibo HE
;
Chao ZHOU
Author Information
1. 四川省川北医学院附属医院药剂科，南充 637000
- From:
International Journal of Traditional Chinese Medicine
2020;42(11):1119-1124
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize water extraction and alcohol precipitation technology of Xiaoaiping capsules. Methods:With the content of Tenacissoside G and dry extract yield rate as the index, to investigate the effects of extraction times, extraction time and the amount of water on extraction technology by orthogonal test; and investigate the influence of the concentration of alcohol precipitation, the relatively density of concentrated liquid and storage time on alcohol precipitation technology by orthogonal test.Results:The optimal water extraction technology was 6-fold water, decocting 3 times for 1.5 h each time. The optimal alcohol precipitation technology was concentrating the water extraction to the density of 1.15 (60 ℃), and add alcohol after cooling with 70% alcohol standing for 12 hand then removing the precipitation.Conclusions:The optimized water extraction and alcohol precipitation process is stable, feasible and reproducible, which could provide reference for the extraction and purification of Xiaoaiping capsules.
