Serotonin Outside the Central Nervous System.
- Author:
Hoo Rim SONG
1
;
Young Sup WOO
;
Won Myong BAHK
Author Information
1. Department of Psychiatry, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. wmbahk@catholic.ac.kr
- Publication Type:Review
- Keywords:
Serotonin;
Cardiovascular;
Gastrointestinal;
Endocrine;
Skeletal
- MeSH:
Biological Processes;
Central Nervous System;
Enterochromaffin Cells;
Gastrointestinal Tract;
Glucose;
Neurotransmitter Agents;
Receptors, Serotonin;
Serotonin
- From:Korean Journal of Psychopharmacology
2012;23(2):45-50
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Most serotonin is found outside the central nervous system and functions much more than a neurotransmitter. Peripheral serotonin is produced by enterochromaffin cells in the gastrointestinal tract and secreted into blood. Serotonin, as a circulating amine, takes part in numerous biological processes including cardiovascular function, bowel motility, glucose metabolism and skeletal change. Serotonin signaling is regulated by serotonin receptors and serotonin transporters in multiple body organs. The drugs that manipulate the serotonergic system have been developed and used for the treatment of many systemic diseases. The richness of serotonergic modulation in the whole body provide both a pharmacologic opportunity and challenge.
