Clinical study of Xiaochaihu Decoction combined with Tongqiao-Huoxue Decoction in the treatment of cardiac neurosis with syndrome of blood stasis
10.3760/cma.j.cn115398-20190712-00083
- VernacularTitle:小柴胡汤合通窍活血汤加减治疗心脏神经官能症血行郁滞证临床研究
- Author:
Chen YANG
1
;
Shun LONG
;
Jiqun YU
Author Information
1. 河北省中铁山桥集团医院内二科，秦皇岛 066200
- From:
International Journal of Traditional Chinese Medicine
2020;42(7):640-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of Xiaochaihu Decoction combined with Tongqiao-Huoxue Decoction in the treatment of cardiac neurosis with syndrome of blood stasis and the effect on serum levels of inflammatory cytokines. Methods:A total of 84 patients with cardiac neurosis, who were admitted to Zhongtieshanqiao Group Hospital, were randomly devided intoto the observation group (42 cases) and the control group (42 cases) withthe random number table method. The control group received Betalog and Glutamine tablet. The observation group took Xiaochaihu Decoction combined with Tongqiao-Huoxue Decoction orally on the basis of the control group. Both groups were treated for 4 weeks. Hamilton depression scale (HAMD) was used to evaluate the degree of depression, Hamilton anxiety scale (HAMA) was used to evaluate the degree of anxiety, and hypersensitive c-reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-α were measured by ELISA, and the clinical efficacy was evaluated. Results:The total effective rate of the observation group was 95.24% (40/42) andthe control group was 75.61% (31/41). The difference between the two groups was statistically significant ( χ2=4.973, P=0.026). After the treatment, scores of HAMD and HAMA of the observation group were signifcantly lower than that of the control group ( t values were 6.579, 8.941, respectively, all Ps<0.01), and scores of impatience, headache, insomnia, forgetfulness, and chest and rib pain were significantly lower than those of the control group ( t values were 7.888, 8.777, 8.836, 9.964, respectively, all Ps<0.01). After the treatment, serum levels of hs-CRP and TNF-α in the observation group were significantly lower than that of the control group ( t values were 5.847, 8.453, respectively, all Ps<0.01). Conclusions:Xiaochaihu Decoction combined with Tongqiao-Huoxue Decoction can relieve the clinical symptoms of cardiac neurosis, and down-regulate serum levels of hs-CRP and TNF-α.
