Clinical study of Bushen-Tianjing-Huayu Decoction combined with conventional western medicine in the treatment of type 2 diabetes mellitu with osteoporosis
10.3760/cma.j.cn115398-20190402-00013
- VernacularTitle:补肾填精化瘀汤结合西医常规疗法治疗2型糖尿病合并骨质疏松症临床研究
- Author:
Ying SHEN
1
;
Yun ZHANG
;
Junfei XU
Author Information
1. 上海市嘉定区马陆镇社区卫生服务中心 201801
- From:
International Journal of Traditional Chinese Medicine
2020;42(6):535-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of Bushen-Tianjing-Huayu Decoction combined with conventional western medicine in the treatment of type 2 diabetes mellitus with osteoporosis. Methods:A total of 83 patients with type 2 diabetes mellitus and osteoporosis who met the inclusion criteria in the Community Health Service Center of Malu Town from January 2018 to December 2018 were recruited and divided into control group (41 cases) and study group (42 cases), according to the random number table method. The control group was treated with conventional western medicine, and the study group was treated with Bushen- Tianjing-Huayu Decoction based on the control group. Both groups were treated for 3 months. The fasting blood glucose and 2 hPG were detected by Accu-Chek Performa roche glucometer, HbAlc was detected by ion exchange chromatography, IL-6 and NO were detected by ELISA, the bone density of femoral neck, L 2-4 and Wards triangle were measured by dual energy X-ray bone mineral density detector. Results:The total effective rate was 90.5% (38/42) in the study group and 70.7% (29/41) in the control group, and the difference between the two groups was statistically significant ( χ2=5.198, P=0.023). After the treatment, the fasting blood glucose, 2 hPG and HbAlc levels in the study group were significantly lower than those of the control group ( t values were 6.822, 6.133 and 5.768, respectively, all Ps<0.001). After the treatment, the bone density levels of femoral neck (0.92 ± 0.10 g/cm 2vs. 0.78 ± 0.09 g/cm 2, t=6.700), L 2-4 (0.98 ± 0.12 g/cm 2vs. 0.87±0.10 g/cm 2, t=4.531) and Wards triangle (0.69 ± 0.08 g/cm 2vs. 0.61 ± 0.06 g/cm 2, t=5.144) in the study group were significantly higher than those of the control group ( P<0.01). The levels of serum IL-6 and NO were significantly lower than those of the control group ( t values were 23.244 and 13.541, all Ps<0.001). Conclusions:The Bushen-Tianjing-Huayu Decoction combined with conventional western medicine can control the blood glucose level, improve bone density, reduce serum IL-6 and NO levels, and improve clinical efficacy for the patients with type 2 diabetes mellitus and osteoporosis.
