The extraction process of Huoxue-Sanyu effervescent tablets by orthogonal test combined with artificial neural network
10.3760/cma.j.cn115398-20191227-00211
- VernacularTitle:正交试验联合人工神经网络优选活血散瘀泡腾片提取工艺
- Author:
Wei PENG
1
;
He TU
;
Zhong ZHANG
;
He ZHU
;
Xu ZHOU
;
Mingquan WU
Author Information
1. 四川省骨科医院中药研究室，成都 610041
- From:
International Journal of Traditional Chinese Medicine
2020;42(6):573-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the extraction process of Huoxue-Sanyu effervescent tablets. Methods:The hydroxysafflor yellow A content, paeoniflorin and dry extract yield were used as the evaluation indexes, by using analytic hierarchy process (AHP) method, integrative graded indicators method combined with orthogonal test and back propagation (BP) artificial neural network. To optimize the technics parameters, such as the amount of water, extraction time and frequency.Results:Paeoniflorin and hydroxysafflor yellow A showed good linear relation in the range of 0.079 5-1.590 4 μg and 0.038 5-1.539 2 μg respectively, with the average recovery rates of 98.18% and 96.22%. RSD was 0.77% and 1.31% respectively. The optimum extraction technic was 9 times of water, 3 times of heating reflux extraction, and each extraction last for 1 hour. Conclusions:The optimized combined method of orthogonal experiment and BP artificial neural network is practical with high efficiency. The optimal extraction process is stable and reasonable.
