Evaluation of therapeutic effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection on coronary atherosclerotic heart disease by using propensity scores
10.3760/cma.j.cn115398-20180920-00097
- VernacularTitle:基于倾向性评分的丹参川芎嗪注射液治疗冠状动脉粥样硬化性心脏病的疗效评价研究
- Author:
Min LI
1
;
Yanming XIE
;
Zhifei WANG
;
Yang GAO
;
Hongyan XU
;
Yan ZHUANG
Author Information
1. 中国中医科学院中医临床基础医学研究所，北京 100700
- From:
International Journal of Traditional Chinese Medicine
2020;42(5):475-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection on coronary heart disease in real world.Methods:Took the patients data with coronary heart disease of 24 tertiary-class A hospitals’ information system from October 2006 to December 2015 as the research targets. The patients injected by Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection were selected as the observation group, and who were not injected were selected as the control group with ratio of 1:1, the same number on gender, similar age (+5 years difference) and similar condition upon hospitalization. Taking medication efficacy as the outcome evaluation index, the 30 confounding factors in this study were controlled by propensity scores, including hospital admission, co-morbidity, co-medication, occupation, cost category, and total hospitalization costs. Comparative analysis of the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection on the clinical outcome of coronary heart disease by classical logistic regression and logistic regression weighted by propensity score.Results:30 confounding factors were identified and balanced, and 7 confounding factors were most affected factors that included clopidogrel bisulfate tablets, occupation, inosine tablets, levocarnidine injection, cerebroprotein hydrolysate injection, nitroglycerin and insulin. Both methods of logistic regression demonstrated that patients receiving parenterally administered Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection had improved outcomes compared to those who did not receive the drug ( P<0.05). Conclusions:The study suggestes that the Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection is a potential advantageous therapy in the treatment of coronary heart disease. However, a large amount of unknown confounding variable should be taken into account. Consider this research is a retrospective study, and the results need to be further verified by prospective studies.
