Thymidylate synthase and tumor
10.3760/cma.j.cn371439-20200318-00088
- VernacularTitle:胸苷酸合成酶与肿瘤
- Author:
Zhiguo HUANG
1
;
Kongwang HU
Author Information
1. 安徽医科大学第一附属医院普外科胃肠外科，合肥 230022
- From:
Journal of International Oncology
2020;47(10):615-618
- CountryChina
- Language:Chinese
-
Abstract:
Thymidylate synthase (TS) is a key enzyme in DNA synthesis and is often used as a target for chemotherapy drugs. In a variety of tumors such as non-small cell lung cancer, colorectal cancer, breast cancer, etc, the expression of TS is closely related to the clinical prognosis and chemotherapy drug resistance of patients. Reducing the expression of TS in tumor tissues through various molecular mechanisms has become an important means to improve the efficacy of chemotherapy drugs and improve the clinical prognosis.
