Progress of Legumain in malignant tumors
10.3760/cma.j.cn371439-20200527-00075
- VernacularTitle:Legumain在恶性肿瘤中的研究进展
- Author:
Bingfang YAN
1
;
Wei MENG
;
Xuelian BAI
Author Information
1. 滨州医学院附属医院临床医学实验室 256603
- From:
Journal of International Oncology
2020;47(9):546-549
- CountryChina
- Language:Chinese
-
Abstract:
Legumain, also called asparaginyl endopeptidase, is one new member of the cysteine protease C13 family and plays various roles in human. In recent years, studies have displayed that Legumain is over expressed in a variety of tumors types and promotes the proliferation of tumor cells, tumor invasion and metastasis as well as angiogenesis through varied mechanisms. Further investigation of Legumain will be helpful to elucidate the pathogenesis and progression mechanism of malignant tumors and provide new molecular for targeted therapy of tumors.
